Total CHD in Framingham was defined as angina, unstable angina, MI, or death from CHD and early risk tables used this definition. Some Framingham calculators calculate the risk of overall CVD while some calculate coronary heart disease (CHD) risk. What are you calculating with a Framingham calculator? 2 As with most calculators, family history and weight are not variables and so clinicians must use clinical judgment when these factors are considered important. 1 Another study suggests that using apo B-apo A-I ratio adds little to the predictive value of the Framingham Risk Score. Novel risk factors such as CRP, LpPLA, IL-6, D-dimer, homocysteine, folate, Vitamin B6, leptin and plasminogen are not included, and interestingly a recent publication concludes that their routine measurement are “not warranted for risk assessment”. Another approach used by clinicians is the Framingham risk calculator, which incorporates age, sex, total cholesterol, HDL cholesterol, systolic blood pressure, presence or absence of diabetes, and smoking (yes or no) in a mathematically derived formula to provide a prediction of risk of cardiovascular disease (CVD). Therapeutics Letter 62 outlined an approach to estimate the potential benefits of treating mild hypertension by using the results of a meta-analysis.
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